Moving the Industry Beyond Surface Technology and Into Mechanobiology
Mechanobiology
Mech•an•o•bi•ol•o•gy
(Noun)The emerging field of science at the interface of biology and engineering that focuses on how physical forces and changes in the mechanical properties of cells and tissues contribute to development, cell differentiation, proliferation, and healing.
Hierarchical Surface Roughness
Spans from the macro to nano scale. These surface features have been shown to stimulate increased gene expression of certain osteogenic markers when compared to other interbody surfaces and materials3.
Open architecture Design
Allows for greater graft volume and bone growth throughout the entire construct.
Truss Implant design
Provides maximum strength with a minimal amount of material, which limits imaging artifacts.
Optimized Load distribution
Distribution of load through the implant struts delivers strain to adjacent cellular material which stimulates a mechanobiologic response1,2,9.
Novel Snowshoe Interface
Provides a Snowshoe Interface that distributes load across the endplate minimizing point loading and reducing the risk of subsidence4,5,6,7,8.
Hierarchical Surface Roughness
Surrounds every strut in the truss implant, providing a scaffold for cell adhesion and osteogenesis throughout the entire fusion column.
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Open architecture Design
Surrounds every strut in the truss implant, providing a scaffold for cell adhesion and osteogenesis throughout the entire fusion column.
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
Truss Implant design
Surrounds every strut in the truss implant, providing a scaffold for cell adhesion and osteogenesis throughout the entire fusion column.
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
Optimized Load distribution
Surrounds every strut in the truss implant, providing a scaffold for cell adhesion and osteogenesis throughout the entire fusion column.
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
Novel Snowshoe Interface
Surrounds every strut in the truss implant, providing a scaffold for cell adhesion and osteogenesis throughout the entire fusion column.
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
The 4WEB Difference
Truss Implant Technology provides a synergistic relationship between the hierarchical surface roughness and the truss architecture to create a cascade of osteogenic activity that supports the fusion process over time.
4WEB’s hierarchical surface roughness has been shown to provide an environment that allows for bone growth and fusion3
Under normal physiologic loading conditions, the truss implant distributes strain through the struts to adjacent cellular material, amplifying the osteogenic activity initiated by the implant surface technology.
Additionally, in vitro testing has also shown that stem cells cultured in an osteogenic medium demonstrate increased expression of certain osteogenic markers on 4WEB’s titanium hierarchical surface roughness compared to smooth titanium and smooth PEEK3.
Please note that in vitro and in vivo testing may not be indicative of clinical performance.
